Prescription estriol creamEstriol 0.3% · Vitamin C 5% · Hyaluronic acid 0.5%
Estrogen Face Cream
from $54.99For skin that turned dry, thin and dull as estrogen dropped.
See details and pricingPrescription skincare, prescribed online
Your skin changed. You didn’t.
Prescription estriol, tretinoin and hydroquinone, reviewed by a licensed US provider and compounded by a PCAB-accredited US pharmacy. For when your skin changes faster than you do.
About 5 minutes·Automatic refund if not prescribed
Denise, 52Estrogen Face Cream · 12 weeks · Unretouched
Licensed US providersReview every visit
PCAB-accredited pharmacyCompounded by Chemistry Rx, PA
Batch-testedCertificate of analysis on every box
Ships in 2 business daysAfter approval, in a plain box
It happened faster than anyone warned you.
Hormones shift. Weight comes off. Either way, the face in the mirror can change in a year. Start with what you’re noticing.
The prescriptions
Three that do the heavy lifting.
Prescription tretinoin creamTretinoin 0.05% · Niacinamide · Vitamin C
Fine Line Cream
from $49.99The prescription retinoid dermatologists have used for decades on fine lines and texture.
See details and pricing
Prescription hydroquinone creamHydroquinone 6% · Kojic acid 6% · Niacinamide
Dark Spot Cream
from $54.99For dark spots and melasma. Hydroquinone is no longer sold over the counter in the US.
See details and pricingMost chosen
The Night Set
Estrogen Face Cream plus Fine Line Cream. Two prescriptions, two minutes, every night. One price.
from $89Shop the Night Set
Why prescription
Skincare that has to prove what’s in it.
Store-bought skincare is sold as a cosmetic. It doesn’t need FDA approval before it’s sold, and no one has to verify the percentage on the jar. Your prescription is made for you by a licensed, PCAB-accredited pharmacy and tested before it ships.
- Compounded by Chemistry Rx, a PCAB-accredited pharmacy in Folcroft, PA
- Active ingredients from FDA-registered manufacturers
- Prescribed by a licensed provider who reviews your history
- Batch-tested, with a certificate of analysis for every box
Every batch is tested four ways before it ships.
PotencyPassed
The percentage on the label is what's in the tube.Assay within 90 to 110% of label strengthPurityPassed
Free of harmful bacteria, yeast and mold.Meets USP microbial limitspHPassed
Balanced for nightly use on your face.Within target range for topical useStabilityPassed
Full strength through the use-by date.Beyond-use date verifiedHow it works
- 1
Tell us what changed
A 5-minute online visit. Your skin, your health history, your medications, a few photos.
- 2
A licensed provider reviews it
If a prescription isn't right for you, you get an automatic refund.
- 3
It ships in 2 business days
After approval, from Chemistry Rx, in a plain box.
- 4
Adjust as you go
Message your care team with questions. Your routine can change as your skin does.
Two minutes before bed.
CleanseYour usual gentle cleanser. Pat dry.
TreatA pea-sized amount of your prescription.
SealYour usual moisturizer on top. Then sleep.
Every morning: SPF 30 or higher. Tretinoin and hydroquinone make skin more sensitive to sun.
In their words.
Verified patients. Individual results vary.
“My skin went papery almost overnight. Three months in, it feels like mine again.”
“I'd spent a fortune on serums. This is the first thing that actually touched my sun spots.”
“Two minutes at night. I didn't have to learn a ten-step routine to see a difference.”
Questions, answered plainly.
Do I need to be in menopause?
No. Skin changes can start in your late 30s. Your provider looks at your skin and your history, not a label.
Why does this need a prescription?
Estriol, tretinoin and hydroquinone are prescription-only in the US, so a licensed provider reviews your health history before prescribing.
Who makes it?
Chemistry Rx, a PCAB-accredited compounding pharmacy in Folcroft, Pennsylvania, licensed in all 50 states.
Is estriol a hormone?
Yes. It's a mild estrogen in a low-concentration cream for your face. Your provider reviews your history, including any hormone-sensitive conditions, before prescribing it.
When will I see a difference?
Prescription actives take time. Plan on 8 to 12 weeks of consistent use before judging. Individual results vary.
Still you.Start with a 5-minute online visit.Start your online visitAutomatic refund if not prescribed